Blar i Bergen Open Research Archive på forfatter "Mills, Ian"

Viser treff 1-7 av 7

    • Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediaterisk human prostate cancer 

      Sushentsev, Nikita; McLean, Mary A.; Warren, Anne Y.; Benjamin, Arnold J. V.; Brodie, Cara; Frary, Amy; Gill, Andrew B.; Jones, Julia; Kaggie, Joshua D.; Lamb, Benjamin W.; Locke, Matthew J.; Miller, Jodi L.; Mills, Ian; Priest, Andrew N.; Robb, Fraser J. L.; Shah, Nimish; Schulte, Rolf S.; Graves, Martin J.; Gnanapragasam, Vincent J.; Brindle, Kevin M.; Barrett, Tristan; Gallagher, Ferdia A. (Journal article; Peer reviewed, 2022)
      Hyperpolarised magnetic resonance imaging (HP 13C-MRI) is an emerging clinical technique to detect [1-13C]lactate production in prostate cancer (PCa) following intravenous injection of hyperpolarised [1-13C]pyruvate. Here ...

    • The Interplay Between Prostate Cancer Genomics, Metabolism, and the Epigenome: Perspectives and Future Prospects 

      Singh, Reema; Mills, Ian (Journal article; Peer reviewed, 2021)
      Prostate cancer is a high-incidence cancer, often detected late in life. The prostate gland is an accessory gland that secretes citrate; an impaired citrate secretion reflects imbalances in the activity of enzymes in the ...

    • Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells 

      Amoroso, Francesca; Glass, Kimberley; Singh, Reema; Liberal, Francisco; Steele, Rebecca E.; Maguire, Sarah; Tarapore, Rohinton; Allen, Joshua E.; Van Schaeybroeck, Sandra; Butterworth, Karl T.; Prise, Kevin; O’Sullivan, Joe M.; Jain, Suneil; Waugh, David J.; Mills, Ian (Journal article; Peer reviewed, 2021)
      Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can ...

    • A non-coding RNA balancing act: miR-346-induced DNA damage is limited by the long non-coding RNA NORAD in prostate cancer 

      Fletcher, C.E.; Deng, L.; Orafidiya, F.; Yuan, W.; Lorentzen, M.P.G.S.; Cyran, O.W.; Varela-Carver, A.; Constantin, T.A.; Leach, D.A.; Dobbs, F.M.; Figueiredo, I.; Gurel, B.; Parkes, E.; Bogdan, D.; Pereira, R.R.; Zhao, S.G.; Neeb, A.; Issa, F.; Hester, J.; Kudo, H.; Liu, Y.; Philippou, Y.; Bristow, R.; Knudsen, K.; Bryant, R.J.; Feng, F.Y.; Reed, S.H.; Mills, Ian; de Bono, Bono; Bevan, C.L. (Journal article; Peer reviewed, 2022-03-22)
      Background: miR-346 was identified as an activator of Androgen Receptor (AR) signalling that associates with DNA damage response (DDR)-linked transcripts in prostate cancer (PC). We sought to delineate the impact of miR-346 ...

    • The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study 

      Ioannidou, Anna; Watts, Eleanor L.; Perez-Cornago, Aurora; Platz, Elizabeth A.; Mills, Ian; Key, Timothy J.; Travis, Ruth C.; Tsilidis, Konstantinos K.; Zuber, Verena (Journal article; Peer reviewed, 2022)
      Background Numerous epidemiological studies have investigated the role of blood lipids in prostate cancer (PCa) risk, though findings remain inconclusive to date. The ongoing research has mainly involved observational ...

    • Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse 

      Taavitsainen, S.; Engedal, Nikolai; Cao, S.; Handle, Florian; Erickson, A.; Prekovic, Stefan; Wetterskog, D.; Tolonen, Teemu T.; Vuorinen, E.M.; Kiviaho, A.; Nätkin, R.; Häkkinen, T.; Devlies, W.; Henttinen, S.; Kaarijärvi, R.; Lahnalampi, M.; Kaljunen, H.; Nowakowska, K.; Syvälä, H.; Bläuer, M.; Cremaschi, P.; Claessens, Frank; Visakorpi, Tapio; Tammela, T.L.J.; Murtola, T.; Granberg, K.J.; Lamb, Alastair D.; Ketola, Kirsi; Mills, Ian; Attard, Gerhardt; Wang, W.; Nykter, Matti; Urbanucci, Alfonso (Journal article; Peer reviewed, 2021)
      Prostate cancer is heterogeneous and patients would benefit from methods that stratify those who are likely to respond to systemic therapy. Here, we employ single-cell assays for transposase-accessible chromatin (ATAC) and ...

    • Vascular normalisation as the stepping stone into tumour microenvironment transformation 

      Magnussen, Anette L.; Mills, Ian (Journal article; Peer reviewed, 2021)
      A functional vascular system is indispensable for drug delivery and fundamental for responsiveness of the tumour microenvironment to such medication. At the same time, the progression of a tumour is defined by the interactions ...